Ann Marshak-Rothstein Selected Research

deoxyribonuclease II (DNASE II)

1/2020	Role of Interferon-γ-Producing Th1 Cells in a Murine Model of Type I Interferon-Independent Autoinflammation Resulting From DNase II Deficiency.
2/2017	STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice.
2/2016	Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.
2/2015	Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands.
2/2015	Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.

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Ann Marshak-Rothstein Research Topics

Disease

21	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 04/2002
16	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2020 - 06/2004
15	Inflammation (Inflammations) 11/2021 - 04/2002
13	Bites and Stings (Sting) 01/2022 - 02/2015
5	Infections 11/2021 - 01/2007
5	Arthritis (Polyarthritis) 02/2016 - 10/2012
4	Fibrosis (Cirrhosis) 01/2019 - 11/2010
3	Glaucoma 09/2019 - 03/2011
3	Splenomegaly 02/2016 - 02/2015
3	Neoplasms (Cancer) 12/2007 - 06/2004
1	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2022
1	Skin Diseases (Skin Disease) 01/2022
1	Human Influenza (Influenza) 11/2021
1	COVID-19 11/2021
1	Proteinuria 01/2021
1	Cytopenia 01/2020
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020
1	Neuroinflammatory Diseases 09/2019
1	Corneal Injuries 01/2019
1	Corneal Opacity 01/2019
1	Keratitis 01/2019
1	Pneumonia (Pneumonitis) 01/2019
1	Glomerulonephritis 01/2016
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2015
1	Nephrogenic Fibrosing Dermopathy 11/2015
1	Chronic Renal Insufficiency 11/2015
1	Peritonitis 02/2015
1	Hypertrophy 02/2015
1	Melanoma (Melanoma, Malignant) 02/2015
1	Virus Diseases (Viral Diseases) 05/2012
1	Systemic Scleroderma (Systemic Sclerosis) 11/2010
1	Psoriasis (Pustulosis Palmaris et Plantaris) 09/2009
1	Porcine Reproductive and Respiratory Syndrome (PRRS) 01/2007
1	Disease Progression 11/2005
1	Lymphoma (Lymphomas) 07/2005

Drug/Important Bio-Agent (IBA)

19	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 05/2007
14	AutoantibodiesIBA 01/2021 - 04/2002
10	Fas Ligand Protein (Fas Ligand)IBA 11/2021 - 04/2002
9	Toll-Like Receptors (Toll-Like Receptor)IBA 09/2019 - 04/2005
9	CytokinesIBA 09/2019 - 11/2005
8	RNA (Ribonucleic Acid)IBA 11/2021 - 11/2005
8	Nucleic AcidsIBA 12/2019 - 04/2002
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2002
6	LigandsIBA 01/2018 - 12/2003
5	deoxyribonuclease II (DNASE II)IBA 01/2020 - 02/2015
5	Antigen-Antibody Complex (Immune Complex)IBA 10/2012 - 05/2007
4	AutoantigensIBA 03/2015 - 11/2005
3	InflammasomesIBA 09/2019 - 02/2015
3	Interferon Type IIBA 01/2019 - 05/2012
3	Immunoglobulin G (IgG)IBA 01/2016 - 06/2007
2	InterferonsIBA 01/2022 - 02/2015
2	fas Receptor (CD95 Antigen)IBA 11/2021 - 09/2019
2	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2020 - 01/2019
2	Phosphotransferases (Kinase)IBA 01/2019 - 01/2018
2	pristane (pristan)IBA 02/2015 - 09/2013
2	Pattern Recognition ReceptorsIBA 02/2015 - 01/2007
2	Nuclear Antigens (Extractable Nuclear Antigens)IBA 10/2012 - 03/2012
2	ChromatinIBA 04/2005 - 12/2003
1	OvalbuminIBA 01/2022
1	Small Cytoplasmic RNAIBA 11/2021
1	LipidsIBA 11/2021
1	Metalloproteases (Metalloproteinases)IBA 11/2021
1	bis(3',5')-cyclic diguanylic acidIBA 01/2021
1	Interferon LambdaIBA 12/2019
1	Caspase 8 (Caspase-8)IBA 09/2019
1	Peptides (Polypeptides)IBA 09/2019
1	Retinaldehyde (Retinal)IBA 09/2019
1	Neuroprotective AgentsIBA 09/2019
1	ChemokinesIBA 09/2019
1	Complement System Proteins (Complement)IBA 09/2019
1	ONL1204IBA 09/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	Biological ProductsIBA 01/2018
1	Thymidine Monophosphate (TMP)IBA 01/2016
1	interleukin-21 (interleukin 21)IBA 12/2015
1	Interleukin-13IBA 12/2015
1	Bleomycin (Blenoxane)FDA LinkGeneric 12/2015
1	AsbestosIBA 11/2015
1	Contrast MediaIBA 11/2015
1	NucleotidesIBA 11/2015
1	InterleukinsIBA 11/2015
1	NLR ProteinsIBA 11/2015
1	Silicon Dioxide (Silica)FDA LinkGeneric 11/2015
1	GadoliniumIBA 11/2015
1	EndonucleasesIBA 02/2015
1	HydrocarbonsIBA 09/2013
1	RibonucleoproteinsIBA 11/2012
1	Immunoglobulin M (IgM)IBA 10/2012
1	belimumabIBA 12/2011
1	Poly I-CIBA 11/2010
1	Toll-Like Receptor AgonistsIBA 11/2010
1	Factor V (Coagulation Factor V)IBA 01/2010
1	Transcription Factors (Transcription Factor)IBA 01/2010
1	A-Form DNA (A-DNA)IBA 09/2009
1	EpitopesIBA 01/2007

Therapy/Procedure

4	Therapeutics 01/2021 - 04/2011
2	Microspheres (Microsphere) 09/2019 - 12/2016
2	Immunotherapy 07/2005 - 06/2004
1	Debridement 01/2019
1	Injections 01/2019